Targeting Drug-Tolerant Persister Cells in Lung Adenocarcinoma
Document Type : مقاله پژوهشی
Author
Centre for Molecular Oncology
Abstract
A subpopulation of drug-tolerant persister cells underlies relapse after targeted therapy. We characterised persister states in lung adenocarcinoma using paired single-cell transcriptomic and chromatin-accessibility profiling across eight patient-derived models. Persisters converged on a shared quiescent programme marked by lysosomal expansion and dependence on GPX4. Pharmacological ferroptosis induction depleted the persister reservoir and delayed resistance in vivo.
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Volume 4 (2026), Issue 2
Genomics of CarcinogenesisSpring 2026Pages 13-24
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